中国血液净化

中国血液净化 ›› 2024, Vol. 23 ›› Issue (11): 878-880.doi: 10.3969/j.issn.1671-4091.2024.11.016

• 短篇报道 • 上一篇    

2例双重滤过血浆置换治疗白血病患者严重铁过载报道及文献复习

宋佚凡    陈利婷    张 超    任野萍    王 琴   

  1. 518055 深圳，1深圳大学总医院肾脏病科
  • 收稿日期:2024-06-04 修回日期:2024-09-05 出版日期:2024-11-12 发布日期:2024-11-12
  • 通讯作者: 王琴 E-mail:wangqinmail@vip.163.com
  • 基金资助:
    国家自然科学基金面上项目(82270774)

Leukemia patients with severe iron overload and treated with double filtration plasmapheresis: report of two cases and review of the literature

SONG Yi-Fan, CHEN Li-ting, ZHANG Chao, REN Ye-ping, WANG Qin   

  1. Department of Nephrology, Shenzhen University General Hospital, Shenzhen 518055, China
  • Received:2024-06-04 Revised:2024-09-05 Online:2024-11-12 Published:2024-11-12
  • Contact: 518055 深圳，1深圳大学总医院肾脏病科 E-mail:wangqinmail@vip.163.com

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摘要： 报道2例使用双重滤过血浆置换(double filtration plasmapheresis,DFPP)治疗白血病患者严重铁过载，治疗后铁蛋白显著降低且未见严重不良反应。提示DFPP可能是严重铁过载时快速清除铁蛋白的方法，可以用于祛铁药物治疗欠佳或药物不耐受的铁过载患者。

关键词: 双重滤过血浆置换, 铁过载, 白血病

Abstract: We report two leukemia patients with severe iron overload and successfully treated with double filtration plasmapheresis (DFPP). After the treatment, serum ferritin reduced significantly without any severe complications. We suggest that DFPP is a fast and efficient therapy to remove ferritin, and can be used in severe iron overload patients with poor response or intolerance to drug treatment. 

Key words: Double filtration plasmapheresis, Iron overload, Leukemia

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