目的  探究血清调节活化正常T细胞表达与分泌的趋化因子(regulated on activation, normal T cell expressed and secreted，RANTES)、嗜酸细胞趋化因子1(Eotaxin-1)、中性粒细胞百分比与白蛋白比值(neutrophil percentage to albumin ratio，NPAR)与腹膜透析相关性腹膜炎(peritoneal dialysis-associated peritonitis，PDAP)的相关性和临床转归预测价值。 方法  选择2021年8月—2024年8月于孝感市中心医院就诊治疗的PDAP患者为研究组，根据PDAP患者治疗1年后的转归情况分为良好组和不良组，同期选取未发生腹膜炎的腹膜透析患者作为对照组，采用Pearson相关分析探讨各指标与PDAP的相关性，Logistic回归分析PDAP患者临床转归的影响因素，受试者工作特征曲线分析各指标对PDAP患者临床转归的预测价值。 结果  研究组、对照组均纳入138例患者。研究组血清RANTES、Eotaxin-1、NPAR均高于对照组(t=18.991、13.335、15.725，均P＜0.001)；研究组RANTES与Eotaxin-1(r=0.379、P＜0.001)、NPAR(r=0.412、P＜0.001)呈正相关，Eotaxin-1与NPAR呈正相关(r =0.343、P＜0.001)；不良组血清RANTES、Eotaxin-1、NPAR均高于良好组(t=7.869、7.350、8.260，均P＜0.001)；血清RANTES[OR(95% CI)=2.752(1.211～6.256)，P=0.016]、Eotaxin-1[OR(95% CI)=1.904(1.025～3.537)，P=0.042]、NPAR[OR(95% CI)=3.408(1.230～9.443)，P=0.018]升高是PDAP患者治疗失败的危险因素；血清RANTES、Eotaxin-1、NPAR、三者联合预测PDAP患者临床转归的AUC分别为0.831、0.791、0.889、0.970，三者联合对PDAP患者临床转归的预测价值高于单独预测(Z三者联合-RANTES=4.140、P＜0.001，Z三者联合-Eotaxin-1=4.628、P＜0.001，Z三者联合-NPAR=3.358、P=0.001)。 结论  血清RANTES、Eotaxin-1、NPAR升高与腹膜透析过程中PDAP发生有关，血清RANTES、Eotaxin-1、NPAR升高不利于PDAP患者预后，对PDAP患者临床转归具有潜在的预测价值。

Objective  To investigate the correlation between serum levels of regulated on activation, normal T cell expressed and secreted (RANTES), Eotaxin-1, neutrophil percentage to albumin ratio (NPAR) and peritoneal dialysis-associated peritonitis (PDAP), as well as their predictive value for clinical outcomes.  Methods  Patients with PDAP treated at Xiaogan Central Hospital from August 2021 to August 2024 were selected as the study group. Based on their outcomes one year after treatment, they were divided into a good outcome group and a poor outcome group. Peritoneal dialysis patients without peritonitis during the same period were selected as the control group. Pearson correlation analysis was used to assess the correlation between each marker and PDAP. Logistic regression was used to analyze factors influencing clinical outcomes in PDAP patients. Receiver operating characteristic curves were used to evaluate the predictive value of these markers for clinical outcomes.  Results  A total of 138 patients were included in each of the study group and the control group. Serum levels of RANTES, Eotaxin-1, and NPAR in the study group were significantly higher than those in the control group (t=18.991, 13.335, 15.725, all P<0.001). In the study group, RANTES was positively correlated with Eotaxin-1 (r=0.379, P<0.001) and NPAR (r=0.412, P<0.001), and Eotaxin-1 was positively correlated with NPAR (r=0.343, P<0.001). Serum levels of RANTES, Eotaxin-1, and NPAR in the poor outcome group were significantly higher than those in the good outcome group (t=7.869, 7.350, 8.260, all P<0.001). Elevated serum RANTES (OR=2.752, 95% CI: 1.211～6.256, P=0.016), Eotaxin-1 (OR=1.904, 95% CI: 1.025～3.537, P=0.042), and NPAR (OR=3.408, 95% CI: 1.230～9.443, P=0.018) were risk factors for treatment failure in PDAP patients. The areas under the curve (AUC) for predicting clinical outcomes in PDAP patients were 0.831 for RANTES, 0.791 for Eotaxin-1, 0.889 for NPAR, and 0.970 for the combination of the three. The combined prediction value was significantly higher than that of each alone (Z combination - RANTES=4.140, P＜0.001, Z combination - Eotaxin-1=4.628, P＜0.001, Z combination - NPAR=3.358, P=0.001).  Conclusion  Elevated levels of serum RANTES, Eotaxin-1, and NPAR are associated with the occurrence of PDAP during peritoneal dialysis and are detrimental to the prognosis of PDAP patients. They have potential predictive value for clinical outcomes in PDAP patients.