中国血液净化

›› 2003, Vol. 2 ›› Issue (10): 558-559.

• 论著 • 上一篇    下一篇

维持性血液透析患者左旋肉碱水平与血脂关系的研究

沈 洋 彭立人   

  1. 100020 北京，首都医科大学2002级硕士研究生(沈 洋)100020 北京，首都医科大学附属北京朝阳医院(彭立人)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-10-19 发布日期:2003-10-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-10-19 Published:2003-10-19

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摘要： 目的 观察维持性血液透析（MHD）患者血清游离肉碱（SFC）水平与血脂的关系。方法 采 用随机对照的研究方法选择MHD患者60例，分为治疗组30例、对照组30例，每次透析结束后，治疗组静脉注射左旋肉碱1.0g，对照组静脉注射生理盐水5ml，疗程共12周。应用紫外酶法检测其透析前后的SFC，常规方法检测总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇。结果 治疗组SFC水平显著升高（P<0.01）、总胆固醇、甘油三酯较治疗前显著降低（P<0.05），高密度脂蛋白胆固醇有显著升高（P<0.05 ），低密度脂蛋白胆固醇无显著性变化，对照组血脂四项均无显著性变化。结论 MHD患者普遍存在左旋肉碱缺乏及血脂代谢紊乱，补充左旋肉碱可明显提高脂肪利用，改善脂代谢紊乱的情况。

关键词: 左旋肉碱, 血脂, 血液透析

Abstract: Objective To observe serum free carnitine(SFC) level in maintenance hemodialysis patients and its relation to their serum lipid level. Meathods Sixty maintenance hemodialysis patients were randomly divided into 2 groups, therapy group:L-carnitine 1.0g intravenously infuse after every dialysissession;control group were given saline 5ml. We observed for 12 weeks. The concentration of SFC was tested with ex-violet enzyme technique, and the other index were tested with routine method. Results In therapy group,the concentration of SFC was significantly increased (P<0.01), total cholesterol and triglyceride was decreased (P<0.05), and high density lipoprotein (HDL) in value was higher than in control group (P<0.05). Low density lipoprotein (LDL) did not change significantly, and there is also no significant change of serum lipid level in control group. Conclusion In maintenance hemodialysis patients, L-carnitine absence and metabolism disorder of serum lipid are widespread and its complementation can singnificantly increase the use of fat and improve the disorder condition

Key words: Serum lipid, Hemodialysis