Objective To evaluate and compare the clinical effect of continuous renal replacement therapy (CRRT) and intermittent hemodialysis (IHD) on treating uremia patients accompanied by heart failure. Methods Fourty-eight patients suffered from uremia accompanied by heart failure were divided into two groups. Twenty cases in CRRT group received CRRT therapy. Tuenty-eight cases in IHD group received IHD therapy. Improvement of heart function of two groups after treatment was observed and evaluated. Results The heart function after CRRT was improved obviously and was better than that after IHD. Conclusion The clinical effect of CRRT was more obvious than IHD in improving the heart function of uremia patients accompanied by heart failure.