中国血液净化

›› 2004, Vol. 3 ›› Issue (12): 657-659.

• 论著 • 上一篇    下一篇

重组人红细胞生成素对维持性血液透析患者免疫功能及红细胞CR1分子表达的影响

张 永 吴平勇 张建鄂   

  1. 442000 十堰，郧阳医学院附属太和医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2004-12-12 发布日期:2004-12-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2004-12-12 Published:2004-12-12

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摘要：

目的 研究r-HuEPO对维持性血液透析患者T淋巴细胞亚群及红细胞CR1分子表达的影响。方法 32例维持性血液透析患者作为观察组，20例正常人作为对照组。采用流式细胞仪检测正常对照组、维持性血液透析患者治疗前及r-HuEPO治疗后3个月CD3、CD4、CD8及CD4/ CD8；采用ELISA检测其红细胞CR1分子表达，同时检测治疗前后Hb水平。结果 EPO治疗3个月后，CD4显著升高( P<0.001)， CD8、CD4/CD8降低(P<0.05)；红细胞 CR1分子表达及血Hb的水平均明显升高( P<0.001)。结论 EPO 可通过调节T淋巴细胞及红细胞CR1分子表达来改善维持性血液透析患者的细胞免疫功能。

关键词: 重组人红细胞生成素, 红细胞CR1分子表达, 免疫功能

Abstract:

Objective To investigate the influence of r-HuEPO on T lymphocyte subgroup and complement receptor 1 express on erythrocytes(CR1) in patients undergoing long-term hemodialysis. Methods Thirty-two cases undergoing long-term hemodialysis were as treated group and 20 healthy subjects were as control group. The levels of CD3，CD4，CD8 and CD4/CD8 were examined by flow cytometry before and after 3 months r-HuEPO therapy，while their CR1 were detected by ELISA, Hb was also detected. Results CD4, CR1,Hb were significantly higher after 3 months treating by r-HuEPO than before and that of control group (P<0.001)， while the CD8，CD4/CD8 were lower (CD4/CD8: P<0.05; CD8: P<0.001). Conclusion r-HuEPO might significantly improve T lymphocyte immunity in patients undergoing long-term hemodialysis.

Key words: Erythrocyte, CR1, Immunity function

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