中国血液净化

›› 2006, Vol. 5 ›› Issue (3): 134-136.

• 论著 • 上一篇    下一篇

他汀药物治疗对尿毒症患者微炎症反应的影响

常为民 冯 兵 杨 旭 杨惠标 叶自林
  

  1. 400037 重庆，第三军医大学新桥医院肾内科(现工作单位是重庆市第九人民医院)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-03-12 发布日期:2006-03-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2006-03-12 Published:2006-03-12

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摘要： 目的 探讨他汀药物治疗对尿毒症患者微炎症反应的影响。 方法 选择重庆市第三军医大学新桥医院肾内科终末期肾病患者（ESRD）55例，随机分为对照组和他汀治疗组，另选择20例正常人作为正常对照，监测治疗前后患者炎症因子的变化。结果 与正常人组比较，治疗前尿毒症患者的炎症因子C反应蛋白(CRP)、白介素-1(IL-1)、白介素-6(IL-6)、肿瘤坏死因子a(TNFa)水平均显著升高，而营养学指标（血浆白蛋白、血浆前白蛋白、血红蛋白）含量均显著降低。来适可20mg治疗4月，虽然治疗组患者血脂、血糖无明显改变，但CRP、IL-1、IL-6、TNF-a含量明显减少，血浆白蛋白、血浆前白蛋白、血红蛋白明显升高，同时患者肌酐尿素氮含量也呈下降趋势。结论 他汀治疗可以显著抑制尿毒症患者微炎症反应、改善营养状态。

关键词: 尿毒症, 微炎症, 他汀

Abstract: Objective To investigate the effect of statin therapy on microinflammation in the patients with uremia. Methods Fifty-five uremic patients were randomly divided into control patient groups (CPG,n=27) and statin therapy group( STG,n=28),20 healthy people as the normal control group(NCG,n=20). The concentrations of serum C-reactive protein (CRP), interleukin-1(IL-1), interleukin-6 (IL-6) and tumor necrosis factor-a(TNF-a) were detected by radioimmunoassay. Results Compared with the NCG, the concentrations of CRP, IL-1, IL-6 and TNF-a in pateints of CPG and STG before statin treatment were much higher than these in NCG, and meanwhile the concentrations of plasma albumin, proalbumin and hemoglobin in patients of CPG and STG were significantly lower than those in NCG. The concentrations of total cholesterol(TC), triglyceride low density lipoprotein-cholesterol (LDL-C) and serum glucose had no difference between CPG and STG. The concentrations of CRP, IL-1, IL-6 and TNF-a decreased markedly,and the concentrations of plasma albumin, proalbumin and hemoglobin increased significantly in pateints of STG after being treated with fluvastatin (20mg/d) for 4 months, and the concentrations of creatinine and urea nitrogen also decreased slightly. Conclusion The microinflammation in patients with uremia could be inhibited effectively by statin treatment.

Key words: Microinflammation, Statin

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