中国血液净化

›› 2007, Vol. 6 ›› Issue (3): 140-141.

• 论著 • 上一篇    下一篇

静脉与口服维生素C对维持性血液透析患者铁超负荷的疗效观察

陈 英 陈 星 符 晓 刘 虹 成梅初   

  1. 410001 长沙，中南大学湘雅二医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-03-12 发布日期:2007-03-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2007-03-12 Published:2007-03-12

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摘要： 目的 观察静脉与口服维生素C(VitC)治疗维持性血液透析(MHD)铁超负荷患者疗效。 方法 选择中南大学湘雅二医院肾内科行血液透析患者血清铁蛋白(SF)＞800ng/ml和(或)转铁蛋白饱和度(TSAT)＞50%30例，随机分为3组，对照组(n=10)、口服组(n=10)和静脉组(n=10)。观察用药前后SF、TSAT、血红蛋白(Hb)、红细胞压积(Hct)和血浆丙二醛(MDA)的变化。 结果 治疗12周后，静脉组SF、TSAT降低，Hb、Hct升高，与对照组、口服组差异有显著性(P＜0.01)；口服组SF、TSAT、Hb、Hct稍有改善，与对照组比较无统计学意义(P＞0.05)而PMDA、PSOD无统计学意义。结论 MHD铁超负荷患者静脉滴注VitC优于口服。

关键词: 维生素C, 血液透析, 铁超负荷

Abstract: Objective To evaluate the effect of intravenous and oral vitamin C on maintenance hemodialysis(MHD) patients with iron overload. Methods Thirty MHD patients with serum ferritin (SF)＞800ng/ml and/or transferrin saturation (TSAT)＞50% were randomly divided into control group, oral group, and intravenous group. The levels of SF，TSAT, hemoglobin (Hb) and hematocrit (Hct) in each group were assessed before and after the therapy. Results The levels of SF and TSAT decreased after 12-week therapy with the improvement of Hb and Hct in the intravenous group, which had significant difference comparing with both control and oral group (P＜0.01). SF, TSAT, Hb and Hct in oral group were improved slightly but no significant difference could be observed (P＞0.05). Conclusion Intravenous vitamin C supplement is better than oral vitamin C on MHD patients with iron overload.

Key words: Hemodialysis, Iron overload

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