【摘要】目的 探讨含糖透析液对糖尿病透析患者发生透析低血糖和低血压的影响，及其代谢指标的变化。方法 对17例维持透析的糖尿病患者进行自身对照试验，前2月使用无糖透析液，后2月换成含糖5.5 mmol/L的透析液，比较前后患者透析低血糖和低血压的发生率，以及代谢指标的变化。 结果 使用无糖透析液时，患者发生透析低血糖和低血压分别为7.6%和18.3%；使用含糖透析液后，患者发生透析低血糖和低血压明显下降，分别为1%和10.7%，P＜0.01和P＜0.05。而糖化血红蛋白和血脂等代谢指标则无明显变化，P＞0.05。结论 在糖尿病肾病的透析患者使用含糖透析液，有利于防止透析低血糖和低血压，而对患者代谢无明显影响。

【Abstract】 Objective To explore the influence of glucose-added dialysate on incidences of intradialytic hypoglycemia and hypotension and on metabolic parameters in hemodialysis patients with diabetic nephropathy. Methods Self-control study was conducted in 17 patients with diabetic nephropathy on hemodialysis. The patients were dialyzed with glucose-free dialysate for a period of 2 months, and then were changed to glucose-added dialysate for another period of 2 months. The incidences of intradialytic hypoglycemia and hypotension and the changes of metabolic parameters were compared between the two periods. Results The incidences of intradialytic hypoglycemia and hypotension were 7.6% and 18.3%, respectively, after the period using glucose-free dialysate; the incidences decreased to 1% (P<0.01) and 10.7% (P<0.05), respectively, after the period using glucose-added dialysate. Metabolic parameters including glycosylated hemoglobin and blood lipid profiles remained unchanged (P>0.05). Conclusion Hemodialysis with glucose-added dialysate is beneficial to maintain normal blood glucose and blood pressure in patients with diabetic nephropathy during hemodialysis, but their metabolic parameters remain unchanged.