【摘要】目的 观察便携式连续性血液净化机在连续性肾脏替代治疗(continuous renal replacement treatment，CRRT)过程中的安全性、稳定性和有效性并对机器的性能进行综合评价。 方法 通过动物犬实验，验证该机器在陆地平稳的环境以及陆地模拟震荡的环境下，进行短时间(8h)、长时间(24h)和超长时间(72h)不间断CRRT治疗时的安全性、有效性和稳定性。 结果 便携式连续性血液净化机不管是在平稳环境下还是在模拟震荡的环境下进行短时间或长时间工作其性能均十分稳定，安全性好。置换液流量控制和脱水精度均达到国家行业标准。实验犬在治疗中生命体征平稳；Na+、Cl椫瘟魄昂笪廾飨圆钜(P＞0.05)；K+、Cr、BUN在治疗后明显下降(P＜0.05)。 结论 便携式连续性血液净化机在陆地模拟震荡环境下工作正常，性能稳定，治疗安全、有效。

【Abstract】 Objective To comprehensively evaluate the safety, stability and validity of the portable continuous blood purification machine in continuous renal replacement treatment (CRRT) by animal experiments. Methods We conducted dog experiments to evaluate the safety, stability and validity of the portable continuous blood purification machine by running the machine for CRRT under a stable land environment and a simulated concussion environment for short period of time (8h), relatively long period of time (24h), and long period of time (72h). Results The safety and stability of the machine were perfect when it worked under a stable land environment and a simulated concussion environment for short and long period of time. The control of fluid replacement volume and dehydration accuracy fulfilled the national industrial standards. During the CRRT using this machine, the experimental dogs showed stable vital signs, decrease of serum K+, Cr and BUN (P＜0.05, as compared with those before the treatment), but no changes in serum Na+ and Cl- (P>0.05, as compared with those before the treatment). Conclusions The stability, safety and effectiveness of the portable continuous blood purification machine are satisfactory either under a stable land environment or under a simulated concussion environment.