中国血液净化

›› 2011, Vol. 10 ›› Issue (5): 254-257.doi: 10.3969/j.issn.1671-4091.2011.04.00

• 临床研究 • 上一篇    下一篇

血液透析患者血清软骨寡聚基质蛋白浓度与血管钙化及心血管事件关系的探讨

赵 伟 戈艳蕾 王田力 孔 炜 王 悦   

  1. 北京大学第三医院肾内科
  • 收稿日期:2011-01-11 修回日期:1900-01-01 出版日期:2011-05-12 发布日期:2011-05-12

The correlation of plasma cartilage oligomeric matrix protein with vascular calcification and cardiovascular events in hemodialysis patients

ZHAO Wei, GE Yan-lei, WANG Tian-li, KONG Wei, WANG Yue.   

  1. 1Department of Nephrology, 2Department of Radiology, Peking University Third Hospital, Beijing 100191, China; 3Department of Pathophysiology, Peking University Health Science Center, Beijing 100191, China
  • Received:2011-01-11 Revised:1900-01-01 Online:2011-05-12 Published:2011-05-12

RichHTML

0

PDF

214

摘要：

目的 探讨血液透析患者血清软骨寡聚基质蛋白(cartilage oligomeric matrix protein, COMP) 浓度与血管钙化及心血管事件的关系。 方法 比较血液透析患者与正常对照组血清COMP浓度的差异，且根据患者血清COMP水平，将北京大学第三医院血液净化中心54例维持性血液透析患者分成高、低浓度两组，胸片法评估两组间基线血管钙化情况，并随访20个月，观察2组间心血管事件的发生情况。 结果 低浓度组和高浓度组的基线血管钙化发生率分别是64.5%(20/31)和91.3%(21/23)，差异有统计学意义(2=5.184,P=0.023)，相应的随访过程中心血管事件的发生率分别是10.4%(3/29)和40.9%(9/22)，差异有统计学意义(2=6.495,P=0.011)。回归分析提示高浓度血清COMP是维持性血液透析患者发生严重心血管事件的预测因素之一。 结论 血液透析患者血清COMP浓度可能是血管钙化及心血管事件的危险因素。

关键词: 血液透析, 血清软骨寡聚基质蛋白, 血管钙化, 心血管事件

Abstract:

Objective To investigate the correlation of plasma cartilage oligomeric matrix protein (COMP) with vascular calcification and cardiovascular events in hemodialysis patients. Methods Plasma COMP levels in hemodialysis patients and normal controls were determined and analyzed. Fifty-four hemodialysis patients were divided into two groups based on plasma COMP level, and they were followed up for 20 months. Vascular calcification of thoracic aorta was evaluated by chest X-ray examination at the beginning and after 20 months. Cardiovascular events were analyzed at the end of the follow-up period. Results At the beginning of the follow-up period, vascular calcification was detected in 20/31 and 21/23 patients in the low COMP group and the high COMP group, respectively (64.5% vs. 91.3%, p=0.023). During the follow-up period, cardiovascular events were found in 3/29 and 9/22 patients in the low COMP group and the high COMP group, respectively (10.4% vs. 40.9%, p=0.011). Regression analysis showed that higher plasma COMP level was one of risk factors for cardiovascular events in maintenance hemodialysis patients. Conclusion Elevated plasma COMP level may be a risk factor for vascular calcification and cardiovascular events in hemodialysis patients.

Key words: Cartilage oligomeric matrix protein, Vascular calcification, Cardiovascular events