中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (08): 407-410.

• 临床研究 • 上一篇    下一篇

维持性血液透析患者炎症-营养不良状态与血小板数量的关系

张国娟,黄雯   

  1. 首都医科大学附属北京同仁医院
  • 收稿日期:2013-03-14 修回日期:2013-05-14 出版日期:2013-08-12 发布日期:2013-08-12
  • 通讯作者: 黄雯 E-mail:huangw6@126.com

The relationship between platelet count and inflammation-malnutrition state in maintenance hemodialysis patients

  • Received:2013-03-14 Revised:2013-05-14 Online:2013-08-12 Published:2013-08-12

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摘要： 目的 观察维持性血液透析患者炎症-营养不良状态与血小板数量的关系。方法 选取首都医科大学附属北京同仁医院血液透析中心稳定的维持性血液透析患者68人，记录患者一般情况，检测血常规、血生化，根据血小板数量将患者分为6组，应用SPSS17.0软件进行统计学分析，采用单因素方差分析比较各组之间一般情况，血液学指标之间的差异，采取spearman相关和线性回归分析患者血小板数量与患者一般情况及相关血液学指标的关系。结果 6组患者之间透析龄、血尿素氮、白蛋白、总胆固醇、低密度脂蛋白胆固醇、高敏C反应蛋白,白细胞、血红蛋白统计学差异显著（p﹤0.05），spearman相关和线性回归分析显示血小板数量与高敏C反应蛋白（β=0.208，p﹤0.05）、低密度脂蛋白胆固醇（β=1.143，p﹤0.05）、白细胞数量（β=0.631，p﹤0.05）呈正相关，与血浆白蛋白（β=-0.320，p﹤0.05）、血红蛋白（β=-0.271，p﹤0.05）呈负相关。结论 在维持性血液透析患者，炎症、营养不良状态与血小板数量增多有关，这可能是其增加血液透析患者心血管事件的机制之一。

关键词: 血液透析, 血小板, 炎症, 营养不良, 心血管疾病

Abstract: Objective To investigate the relationship between platelet count and inflammation-malnutrition state in maintenance hemodialysis patients. Methods 68 Stable maintenance hemodialysis (MHD) patients in Bejing Tongren Hospital were chosen for study. The patients were divided into 6 groups according to the platelet count. The general conditions, complete blood count and serum biochemical indexes were compared between groups using SPSS17.0 software. Results The time duration on dialysis, blood urine nitrogen, serum albumin, total cholesterol, low density lipoprotein-cholesterol(LDL-C),high sensitive C-reactive protein (hsCRP), white blood cell(WBC), blood hemoglobin were different significantly among the six groups. Multiple regression indicated that platelet count positively correlated with hsCRP （β=0.208，p﹤0.05）, LDL-C（β=1.143，p﹤0.05）and WBC（β=0.631，p﹤0.05）, while negatively correlated with serum albumin（β=-0.320，p﹤0.05）and hemoglobin （β=-0.271，p﹤0.05）. Conclusion In MHD patients, inflammation-malnutrition may increase platelet counts, which may be one of the mechanisms that increase the risk of cardiovascular events.

Key words: hemodialysis, platelet, inflammation, malnutrition, cardiovascular disease