中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (10): 566-569.

• 临床研究 • 上一篇    下一篇

高通量透析对维持性血液透析患者血脂和微炎症状态的影响

王俊霞,张鹏,肖雄木,李国辉,周晓丹   

  1. 河南科技大学第一附属医院血液净化科
  • 收稿日期:2013-03-01 修回日期:2013-05-02 出版日期:2013-10-12 发布日期:2013-10-12
  • 通讯作者: 王俊霞 lwx3990@163.com E-mail:lwx3990@163.com
  • 基金资助:

    洛阳市科技攻关项目（1001011A-6）

Effect of high flux hemodialysis on lipid metabolism and micro-inflammatory state in maintenance hemodialysis patients

  • Received:2013-03-01 Revised:2013-05-02 Online:2013-10-12 Published:2013-10-12

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摘要： 目的 研究高通量透析对维持性血液透析患者血脂和微炎症状态的影响。方法 将80例MHD患者随机分为高通量透析组（high flax hemodialysis HFHD）和低通量透析组（low flax hemodialsis LFHD），治疗6个月，观察两组患者微炎症状态和血脂的变化。结果 治疗6个月后，HFHD组超敏C反应蛋白（HSCRP）、全段甲状旁腺素（iPTH）、甘油三酯（TG）、载脂蛋白A、胆固醇、β2MG、均较LFHD组下降，血红蛋白较LFHD组上升明显。HFHD组急性感染和心脑血管事件的发生率亦低于LFHD组，差异有统计学意义。结论 高通量透析能改善MHD患者微炎症状态和血脂状况，减少急性感染和心脑血管事件的发生。

关键词: 高通量透析, 维持性血液透析, 微炎症状态, 血脂, 心脑血管事件

Abstract: ABSTRACT Objective To investigate the effect of high flux hemodialysis on lipid metabolism and micro-inflammatory state in maintenance hemodialysis patients. Methods A total of 80 MHD patients were randomly divided into two groups :high flux hemodialysis (HFHD)group ,and low flux hemodialysis (LFHD) group .the treatment lasted 6 months .Changes of the parameters for lipid metabolism and micro-inflammatory state were observed before and after the treatment in two groups . Results After 6 months ,high sensitive creactive protein ( hsCRP)、 intact parathyroid hormone (iPTH )、triglyceride (TG)、 total cholesterol (TC)、β2-microglobulin (β2MG)、 Apolipoprotein A(APOP-A) were significantly lower in HFHD group than those in LFHD group ,and than those in HFHD group before treatment (P<0.01),while hemoglobin(HGB) were significantly higher in HFHD. The incidence of acute infection and cardiovascular events were lower in HFHD group than in LFHD group (P<0.01). Conclusions High flux hemodialysis can not only improve micro-inflammatory state and dyslipidema but also

Key words: high flux hemodialysis, maintenance hemodialysis, lipid metabolism, micro-inflammatory state, cardiovascular events