中国血液净化

中国血液净化 ›› 2024, Vol. 23 ›› Issue (07): 524-528.doi: 10.3969/j.issn.1671-4091.2024.07.008

• 临床研究 • 上一篇    下一篇

维持性血液透析患者并发腹主动脉钙化危险因素的Meta分析

黄欣萍    邱承高    关海天    张 雷    苏 珊    谢琬娜    米兰岚   

  1. 543000 梧州，1梧州市工人医院肾内科
  • 收稿日期:2024-01-25 修回日期:2024-04-28 出版日期:2024-07-12 发布日期:2024-07-12
  • 通讯作者: 邱承高 E-mail:qiuchenggao@163.com
  • 基金资助:
    梧州市科学研究与技术开发计划项目(201702036)

The risk factors for abdominal aortic calcification in maintenance hemodialysis patients: a Meta-analysis

HUANG Xin-ping, QIU Cheng-gao, GUAN Hai-tian, ZHANG Lei, SU Shan, XIE Wan-na, MI Lan-lan   

  1. Department of Nephrology, Wuzhou Workers' Hospital, Wuzhou 543000, China
  • Received:2024-01-25 Revised:2024-04-28 Online:2024-07-12 Published:2024-07-12
  • Contact: 543000 梧州，1梧州市工人医院肾内科 E-mail:qiuchenggao@163.com

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摘要： 目的  系统性分析我国维持性血液透析(maintenance hemodialysis，MHD)患者并发腹主动脉钙化(abdominal aorta calcification，AAC)的危险因素。 方法 通过计算机对PubMed、Embase、Web of Science、中国知网、中国生物医学文献数据库CBM、万方等数据库检索关于中国MHD患者并发AAC危险因素的文献(时限为建库至2023年5月)，采用纽卡斯尔-渥太华量表(Newcastle-Ottawa scale，NOS)、美国卫生保健质量和研究机构评价标准(agency for healthcare research and quality，AHRQ)进行方法学文献质量评价。采用RevMan 5.3软件进行Meta分析。 结果 共纳入15篇文献，其中10篇中文文献，5篇英文文献，包含2848例研究对象。Meta分析结果显示高龄(OR=1.080，95% CI：1.050～1.110，P＜0.001)、长透析龄(OR=1.020，95% CI：1.010～1.040，P=0.008)、吸烟(OR=1.900，95% CI：1.440～2.500，P＜0.001)、高体质量指数(body mass index，BMI)(OR=1.200，95% CI：1.050～1.110，P=0.001)、血钙升高(OR=14.140，95% CI：7.340～27.260，P＜0.001)、血磷升高(OR=6.010，95% CI：2.040～17.750，P=0.001)、甲状旁腺激素升高(OR=1.310，95% CI：1.010～1.700，P=0.040)以及血镁(OR=0.490，95% CI：0.400～0.590，P＜0.001)、25羟基维生素D3降低(OR=0.760，95% CI：0.610～0.950，P=0.020)为MHD患者并发AAC的危险因素。 结论  维持性血液透析患者并发腹主动脉钙化的影响因素较多，应重点关注高危人群，进行针对性、个性化干预，延缓MHD患者腹主动脉钙化的进展。

关键词: 维持性血液透析, 腹主动脉钙化, 危险因素

Abstract: Objective  To systematically analyze the risk factors for abdominal aortic calcification (AAC) in Chinese maintenance hemodialysis (MHD) patients.   Methods  PubMed, EMBASE, Web of Science, CNKI, CBM, Wanfang and other databases were searched from establishment of the database to May 2023 by computer to retrieve the literature relating to the risk factors for AAC in Chinese MHD patients. The Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ) were used to evaluate the methodological quality of the literature. Meta-analysis was performed using RevMan5.3 software.  Results  A total of 15 articles were obtained, including 10 Chinese articles and 5 English articles and encompassing 2,848 subjects. The results of Meta-analysis showed that older age (OR=1.080, 95% CI: 1.050～1.110, P<0.001), longer dialysis age (OR=1.020, 95% CI: 1.010～1.040, P=0.008), smoking (OR=1.900, 95% CI: 1.440～2.500, P<0.001), higher body mass index (BMI) (OR=1.200, 95% CI: 1.050～1.110, P=0.001), increased blood calcium (OR=14.140, 95% CI: 7.340～27.260, P<0.001), elevated blood phosphorus (OR=6.010, 95% CI: 2.040～17.750, P=0.001), elevated parathyroid hormone (OR=1.310,95% CI:1.010～1.700,P=0.040), elevated blood magnesium(OR=0.490, 95% CI:0.400～0.590, P<0.001) and decreased 25-hydroxyvitamin D3 (OR=0.760, 95% CI: 0.610～0.950, P=0.020) were the risk factors for AAC in MHD patients.  Conclusion  There are many influencing factors for AAC in MHD patients. We should focus on the high-risk groups and carry out targeted and personalized interventions to delay the progress of AAC in MHD patients.

Key words: Maintenance hemodialysis, Abdominal aortic calcification, Risk factor

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