中国血液净化

中国血液净化 ›› 2026, Vol. 25 ›› Issue (05): 407-410.doi: 10.3969/j.issn.1671-4091.2026.05.009

• 综述 • 上一篇    下一篇

残余胆固醇与慢性肾脏病患者心血管病变关系的研究进展

王志刚   王景福   

  1. 1. 承德医学院附属医院
    2. 承德医学院附属医院肾脏内科
  • 收稿日期:2025-09-23 修回日期:2026-01-18 出版日期:2026-05-12 发布日期:2026-05-12
  • 通讯作者: 王景福 E-mail:wangjingfu1968@sina.com
  • 基金资助:
    2023年度河北省医学科学研究课题计划(20231382)

Research progress in the relationship between remnant cholesterol and cardiovascular disease in patients with chronic kidney disease

WANG Zhi-gang, WANG Jing-fu   

  1. Department of Nephrology, The Affiliated Hospital of Chengde Medical College, Chengde 067000, China
  • Received:2025-09-23 Revised:2026-01-18 Online:2026-05-12 Published:2026-05-12
  • Contact: 067000 承德，1承德医学院附属医院肾内科 E-mail:wangjingfu1968@sina.com

摘要： 残余胆固醇(remnant cholesterol,RC)是富含三酰甘油的脂蛋白胆固醇，以禁食状态下的中间密度脂蛋白(intermediate density lipoprotein,IDL)和极低密度脂蛋白(very low density lipoprotein,vLDL)及非禁食状态的乳糜微粒残余物为存在形式。目前RC主要通过计算获取，即RC=总胆固醇(total cholesterol，TC)-高密度脂蛋白胆固醇(high-density lipoprotein cholesterol，HDL-C)-低密度脂蛋白胆固醇(low-density lipoprotein cholesterol，LDL-C)。RC是心血管病变的重要危险因素，心血管并发症是慢性肾脏病(chronic kidney disease，CKD)患者首位死亡原因。本文就CKD患者在不同疾病状态下的血脂特点及RC水平与心血管并发症的关系进行综述，以期为慢性肾脏病患者心血管并发症的早期识别、精准干预提供新思路。

关键词: 残余胆固醇, 心血管疾病, 慢性肾脏病, 降脂治疗

Abstract: Remnant cholesterol (RC) is the cholesterol component of triglyceride-rich lipoproteins, existing in the form of intermediate-density lipoprotein (IDL) and very low-density lipoprotein (vLDL) in the fasting state, and as chylomicron remnants in the non-fasting state. Currently, the primary method  to obtain RC content is through the calculation of RC=total cholesterol (TC) - high-density lipoprotein cholesterol (HDL-C) - low-density lipoprotein cholesterol (LDL-C). RC is a significant risk factor for cardiovascular diseases, while cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD). This article reviews the characteristics of blood lipids and the relationship between RC level and cardiovascular complications in CKD patients under various disease conditions, aiming to provide new insights into early identification and precise intervention of cardiovascular complications in CKD patients.

Key words: Remnant cholesterol, Cardiovascular disease, Chronic kidney disease, Lipid-lowering the-rapy

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