中国血液净化

›› 2007, Vol. 6 ›› Issue (9): 481-483.

• 论著 • 上一篇    下一篇

终末期肾病腹膜透析患者微炎症状态与营养状况的关系

焦东梅 李 伟 武尚文 唐珊珊 刘怡芝   

  1. 250001 济南，山东中医药大学第二附属医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-09-12 发布日期:2007-09-12

  • Received:1900-01-01 Revised:1900-01-01 Online:2007-09-12 Published:2007-09-12

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摘要： 目的 探讨终末期肾病(ESRD)长期腹膜透析患者血清C-反应蛋白(CRP)和白细胞介素-6(IL-6)水平变化及与营养状况的关系。方法 检测山东中医药大学第二附属医院肾内科ESRD患者非透析组、腹膜透析组和对照组的CRP、IL-6、血清白蛋白(Alb)、血红蛋白(Hb)、转铁蛋白(TF)、血肌酐(Scr)水平。根据CRP水平将膜透析组分为CRP≤6mg/L组和CRP＞6mg/L组．并比较两组IL-6、Alb、Hb、TF、Scr的水平。结果 腹膜透析组CRP、IL-6水平明显高于非透析组(P＜0.05)和对照组(P＜0.01)，腹膜透析组CRP、IL-6分别与Alb、Hb、TF呈负相关(r＝-0.543～-0.379，P＜0.05)，与Scr无相关关系(r＝0.258、0.245，P＞O.05)。结论 ESRD腹膜透析患者体内存在微炎症状态，CRP、IL-6是终末期肾病腹膜透析患者微炎症状态较好的预测指标，并可反映腹膜透析患者的营养状况。

关键词: 腹膜透析, C-反应蛋白, 白细胞介素-6, 营养状况

Abstract: Objective To investigate serum C-reactive protein ( CRP)，interleukin-6(IL-6) level and their correlation with nutritional status in patients with end-stage renal disease(ESRD) undergoing peritoneal dialysis. Methods The serum levels of CRP，IL-6，albumin(Alb)，hemoglobin(Hb), transferin( TF)，serum creatinine(Scr) were determined in normal controls, patients without peritoneal dialysis and with peritoneal dialysis. The peritoneal dialysis patients were divided into CRP≤6 mg/L group and CRP＞6 mg/L group．Thc levels of IL- 6，Alb，Hb，TF and Scr were compared between this two groups. Results The serum CRP, IL-6 in peritoneal dialysis group were significantly higher than those of non-peritoneal dialysis group(P＜0.05) and normal control group (P＜0.01)． In peritoneal dialysis group CRP and IL- 6 were negatively correlated with Alb、Hb and TF，respectively (r＝-0.543～-0.379，P＜0.05)，but not correlated with Scr (r＝0.258、0.245，P＞0.05). Conclusion There is microinflammatory state with peritoneal dialysis in the ESRD patients. CRP and IL-6 are the better predictive markers of microinflammatory state and nutrition status.

Key words: C-reactive protein, Interleukin-6, Nutritional status

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