中国血液净化

›› 2003, Vol. 2 ›› Issue (6): 319-321.

• 基础研究 • 上一篇    下一篇

细胞间粘附分子-1在腹膜炎症过程中的作用及己酮可可碱的保护效应 

郭志勇 李保春 袁伟杰 崔若兰   

  1. 200433 上海，第二军医大学附属长海医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-06-19 发布日期:2003-06-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-06-19 Published:2003-06-19

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摘要： 目的 探讨细胞间粘附分子-1（ICAM-1）在连续不卧床性腹膜透析（CAPD）患者的腹膜炎症 过程中的作用及己酮可可碱的保护效应。方法 采用体外腹膜间皮细胞（PMC）与巨噬细胞共同培养的方法，观察抗ICAM-1 MAb对巨噬细胞促进PMC增殖的影响及己酮可可碱的保护效应。结果 抗ICAM-1 MAb对巨噬细胞促进PMC的增殖具有抑制作用，呈剂量依赖性；己酮可可碱可抑制IFN-α诱导的PMC与巨噬细胞粘附。结论 ICAM-1 参与、影响腹膜炎症的过程，己酮可可碱在腹腔局部防御过程中发挥重要作用。

关键词: 腹膜间皮细胞, 巨噬细胞, 细胞间粘附分子-1, 己酮可可碱

Abstract: Objective To investigate the role of ICAM-1 in the process of peritoneum inflammation in CAPD patients and protective effects of pentoxifylline PTX.
Methods Peritoneal mesothelial cell(PMC) and macrophage were co-cultured in vitro. We observed the influence of ICAM-1 on activating PMC proliferation by macrophage and protective effect of pentoxifylline. Results The effect of activating PMC proliferation by macrophage was significantly inhibited and dosage-dependent. PTX was found to antagonize IFN-α induced adhesion reaction of PMC and macrophage. Conclusion ICAM-1 plays an important role in pathologic process of peritoneum inflammation. PTX may play an important role in peritoneal local defense and may be a protective agent which have a potential clinical value.

Key words: Macrophage, Intercellular adhesion molecule-1, Pentoxifylline 