中国血液净化

›› 2003, Vol. 2 ›› Issue (8): 427-429.

• 论著 • 上一篇    下一篇

血液透析对尿毒症患者血清NO-2/NO-3水平的影响

姚 刚 　许宏岳 　方 奕 　武晓春

  

  1. 210011 南京，南京医科大学第二附属医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-08-19 发布日期:2003-08-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-08-19 Published:2003-08-19

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摘要： 目的 探讨血液透析对尿毒症患者血清 NO2－/NO3－水平的影响。方法 选择23例尿毒症患 者(血液透析组12例，非血液透析组11例)，测定血液透析组患者透析前，透析10分钟，透析1小时，透析2小时，透析后和非血液透析组患者血清NO2－/NO3－的水平。结果 血液透析组和非血液透析组尿毒症患者血清NO2－/NO3－水平均明显高于正常对照组，分别为(67.0±13.9)umol/l和(86.5±18.2)umol/l，其中非血液透析组高于血液透析组（P＜0.05)。血液透析10分钟时血清 NO2－/NO3－水平明显高于透析前，透析1小时，透析2小时和透析后。血清NO2－/NO3－水平在血液透析前（67.0±13.9）umol/l与血液透析后（60.2±14.1）umol/l相比无统计学差异。结论 尿毒症患者血清NO2－/NO3－水平是升高的，血液透析自身可以导致尿毒症患者出现一过性血清NO2－/NO3－水平的升高，但维持性血液透析可以减少尿毒症患者体内NO的产生。

关键词: 血液透析, 尿毒症, 血清NO2－/NO3－

Abstract: Objective To investigate the effect of hemodialysis(HD) on the serum nitric oxide levels in the uremic patients. Methods Twenty-three uremic patients were selected, including 12 dialysis group patients and 11 non-dialysis Group patients. The serum NO2- /NO-3 levels in dialysis group patients (at the 10 minutes, 1 hour,2 hours, 4 hours after HD and pre-HD)and in non-dialysis group patients were assayed. Results The serum NO2－/NO3－ levels were markedly increased in the uremic patients both the dialysis group and non-dialysis group. The serum NO2－/NO3－ levels was significantly lower in the dialysis patients than non-dialysis patients. The plasma NO2－/NO3－ levels at the 10 minutes after the initiation of HD was significantly higher than that at the 30 minutes,1 hour, 2 hours, 4 hours and pre-HD. No significant differences in serum NO2－/NO3－ levels were found between the pre-HD and after-HD. Conclusion Our study demonstrated that uremic patients have high serum NO2－/NO3－ levels. Maintenance hemodialysis led to significant drop in serum NO2－/NO3－ levels.

Key words: Uremia, Serum NO2－/NO3－ 