中国血液净化

›› 2003, Vol. 2 ›› Issue (8): 430-432.

• 论著 • 上一篇    下一篇

日间CRRT对急性呼吸窘迫综合征患者血浆炎症介质的影响

吴泰华 林洪丽 李 平 于长青 谢 华   

  1. 116001 大连，大连医科大学附属第一医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-08-19 发布日期:2003-08-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-08-19 Published:2003-08-19

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摘要： 目的 探讨日间 CRRT对急性呼吸窘迫综合症患者血浆炎症介质水平的影响。方法 应用 日间CRRT对12例急性呼吸窘迫综合征患者进行治疗，酶联免疫吸附分析方法检测治疗前和治疗后2、4、6、8、12和停止治疗后12小时血浆中TNF-α、IL-1β、6、8的浓度。结果 CRRT治疗2小时后，血浆TNF-α、IL-1β、6、8水平开始下降,至6～8小时达到最低水平， P<0.01，停止 CRRT治疗后12小时上述因子均有不同程度的回升，但仍低于治疗前水平。结论 CRRT对ARDS患者血浆中细胞因子的清除是确切和有效的，并且提示该种透析膜对炎症介质的清除方式以吸附为主。

关键词: 急性呼吸窘迫综合征, 炎症介质, 连续性肾脏替代治疗

Abstract:

Objective To investigate the effects of daytime continuous renal replacement therapy on the plasma level of inflammatory mediators in acute respiratory distress syndrome. Methods Daytime CRRT were used to treat the patients who suffered from ARDS and the TNF-α、IL-1β、6、8 plasma levels were measured by enzyme-linked immunoassay(ELISA)at 0,2,4,6,8,10,12 hour following CRRT and 12 hour post CRRT. Result TNF-α、IL-1β、6、8 plasma levels start to reduce at 2 hour and decreased to lowest levels at 6 hours following CRRT( P<0.001) and slightly elevated at 12 hours post CRRT but still lower than the levels before CRRT. Conclusion CRRT can effectively clearance these inflammatory mediators. The results suggest that the clearance of these mediators may mainly be due to absorption.

Key words: Inflammatory mediators, Continuous renal replacement therapy 