腹膜透析患者血尿酸与动脉僵硬度的相关性研究

›› 2009, Vol. 8 ›› Issue (1): 34-37.

腹膜透析患者血尿酸与动脉僵硬度的相关性研究

唐子勇张爱华田顺立林书洲汪涛

北京大学第三医院肾内科；广州中医药大学第二临床医学院

收稿日期:2008-11-25 修回日期:1900-01-01 出版日期:2009-01-12 发布日期:2009-01-12

Serum uric acid is related to arterial stiffness in peritoneal dialysis patients

TANG Zi-yong, ZHANG Ai-hua, TIAN Shun-li, LIN Shu-zhou, WANG Tao

1Division of Nephrology, Peking University Third Hospital, Beijing 100191 China

Received:2008-11-25 Revised:1900-01-01 Online:2009-01-12 Published:2009-01-12

摘要/Abstract

摘要： 【摘要】目的动脉僵硬是心血管疾病的重要危险因素。本研究探讨腹膜透析患者血尿酸和动脉僵硬度的关系。方法采集158名稳定腹膜透析病人的临床和生化数据，测定其颈-股动脉脉搏波速度(CF-PWV)作为动脉僵硬度的指标。结果根据血尿酸浓度，患者被分为4组。在组间有显著性差异的指标有C反应蛋白(P＜0.05)和CF-PWV(P＜0.01)。Pearson相关分析显示，和CF-PWV明显相关的因素包括收缩压(P＜0.05)和尿酸浓度(P＜0.01)。多元逐步回归分析显示，血尿酸浓度(b=-0.300,P =0.001)和钙磷乘积(b=0.179, P =0.027)是CF-PWV的独立影响因素。结论血尿酸水平和动脉僵硬度有独立的相关关系。血尿酸浓度升高和动脉僵硬度增加有关，可能参与了心血管事件的发生。

关键词: 腹膜透析, 血清尿酸, 动脉僵硬度, 脉搏波速度

Abstract: 【Abstract】 Objectives Arterial stiffness plays a key role in the evolution of cardiovascular diseases. However, it remains unclear if serum uric acid (UA) is related to arterial stiffness in peritoneal dialysis (PD) patients. Methods The relationship between serum UA and arterial stiffness was investigated in 158 stable continuous PD patients. Their clinical and laboratory data were collected, and arterial stiffness was estimated by measuring pulse-wave velocity from right common carotid artery to right femoral artery (CF-PWV). Results Patients were grouped into 4 groups based on serum UA level. C-reactive protein and CF-PWV were different among the 4 groups (P＜0.01). Pearson’s correlation analysis showed that CF-PWV correlated to systolic blood pressure (P＜0.01) and serum UA (P＜0.01). Multivariate regression analysis showed that serum UA (β=-0.300, P=0.001) and calcium-phosphate product (β=0.179, P=0.027) were the independent determinants of CF-PWV. Conclusion Independent correlation exists between serum UA and CF-PWV. Higher serum UA relates to the increase of arterial stiffness, which may contribute to cardiovascular morbidity in PD patients.

Key words: Serum uric acid, Arterial stiffness, Pulse wave velocity

唐子勇张爱华田顺立林书洲汪涛. 腹膜透析患者血尿酸与动脉僵硬度的相关性研究[J]. , 2009, 8(1): 34-37.

TANG Zi-yong;ZHANG Ai-hua;TIAN Shun-li;LIN Shu-zhou;WANG Tao. Serum uric acid is related to arterial stiffness in peritoneal dialysis patients[J]. , 2009, 8(1): 34-37.