中国血液净化

›› 2002, Vol. 1 ›› Issue (8): 7-9.

• 论著 •    下一篇

腹膜透析患者CA125水平及腹膜转运功能的纵向观察

张爱华 范敏华 郑丹侠 杨雪玲   

  1. 100083 北京，北京大学第三医院肾内科（张爱华 范敏华 郑丹侠）； 消化科(杨雪玲)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2002-08-19 发布日期:2002-08-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2002-08-19 Published:2002-08-19

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摘要： 【摘要】目的 纵向观察腹膜透析（简称腹透）患者腹膜透出液CA125（d-CA125）水平和腹膜转运功能的变化及其相关性。方法 d-CA125浓度测定采用微量酶免疫方法，腹膜转运功能判定采用 4h 腹透液肌酐/血肌酐比率（4D/P Cr）。 结果 观察2年后d-CA125浓度及表现率较2年前有显著下降，腹膜转运功能有显著增加；感染性腹膜炎时d-CA125浓度显著升高，感染控制后又恢复至原来水平； 2年前及2年后d-CA125浓度及表现率均与腹膜转运功能无显著相关。结论 d-CA125 水平随腹透时间延长而降低腹膜转运功能随腹透时间延长而增加，间皮细胞受损可能与腹膜转运功能的变化无关。

关键词: 腹膜透析, CA125, 转运功能

Abstract:

【Abstract】Objective To longitudinal observe the CA125 l evels and peritoneal transport function of peritoneal dialysis patients. Methods Peritoneal dialysis effluents CA125 levels (d-CA125) were measured by micro-particle enzymic immune assay, peritoneal transport function was judged by 4hours dialysate creatinine/serum creatinine ratio (4h D/P Cr). Results d-CA125 concentration and appearance rate in 4hours dwell-time were signficant lower than that of 2 years ago; There was significant increase in 4h D/PCr after 2 years; d-CA125 concentration who suffered from infective peritonitis were significantly increased and d-CA125 levels reduced to the usual levels after peritonitis recovery; CA125 levels had no correleted with 4h D/PCr both 2 years ago and after 2 years. Conclusion d-CA125 levels decreased with peritoneal dialysis duration while peritoneal transport function increased by longitudinal observation.. Injuries of peritoneal mesothelial cells might not be result from the increase of peritoneal transport function.

Key words: CA125, Peritoneal transport function