中国血液净化

›› 2002, Vol. 1 ›› Issue (8): 10-13.

• 论著 • 上一篇    下一篇

HB-H-6 树脂血浆灌流吸附胆红素的动物实验

李 涛 杜 智 回建峰 李 隽 崔润海 付 立 宋继昌   

  1. 300170 天津，天津市第三中心医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2002-08-19 发布日期:2002-08-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2002-08-19 Published:2002-08-19

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摘要： 【摘要】目的 探讨HB-H-6树脂血浆灌流治疗黄疸犬动物模型的有效性和安全性。方法 HB-H-6树脂经过筛、酸、碱、乙醇、冷热水和高压灭菌处理，黄疸犬动物模型采用胆总管-腔静脉搭桥术，灌流方式采用血浆灌流。结果 总胆红素下降82%，直接胆红素下降76%，间接胆红素下降97%，对蛋白质没有明显吸附，对血常规、凝血指标、血气分析和钠、氯、磷没有明显影响；对钾、钙和镁吸附明显。结论 HB-H-6树脂对胆素菜素吸附率高，对治疗黄疸犬动物模型安全有效，但对钾、钙和镁吸附明显，应注意补充。

关键词: HB-H-6树脂, 血浆灌流, 胆红素

Abstract: 【Abstract】Objective To explore the efficacy and safety of HB-H-6 resin plasma perfusion for the treatment of jaundice dog animal model. Methods HB-H-6 resin was disposed by screening, acid, aldali, alcohol, cool warm water treatment and high pressures sterilization, jaundice dog animal model was established by the operation of common bile duct and caval vein connection, and perfusied with plasma perfusion techinque. Results After treatment, Total Bilirubin decreased by 82%, Direct Bilirubin and Indirect Bilirubin declined by 76% and 97% respectively; there was no significant absorptive effect on protein, no significant effect on blood regular test, coagulation, blood gas analysis, sodium, chlorine and phosphor, but have high absorptive effect on potassium calciumand magnesium. Conclusions HB-H-6 resin was shown to have high bilirubin absorption properties, it was safe and effective to treat the jaundice dog animal model,but we have to supply with potassium，calcium and magnesium because of significant absorptive effect on them.

Key words: Resin plasma perfusion, Bilirubin