中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (04): 203-206.doi: 10.3969/j.issn.1671-4091.2013.04.00

• 临床研究 • 上一篇    下一篇

维持性血液透析抑郁患者血清部分细胞因子的改变及其临床意义

张琴1,范亚平2,凌凯1   

  1. 1. 南通大学附属吴江第一人民医院 苏州市吴江第一人民医院肾内科
    2. 南通大学附属医院
  • 收稿日期:2012-11-26 修回日期:2013-01-29 出版日期:2013-04-12 发布日期:2013-07-01
  • 通讯作者: 范亚平fanyp19107@medmail.com.cn E-mail:fanyp19107@medmail.com.cn

Study of changes and clinical significances of serum cytokines in the maintenance hemodialysis patients with depression

  • Received:2012-11-26 Revised:2013-01-29 Online:2013-04-12 Published:2013-07-01
  • Contact: Ya-ping FAN E-mail:fanyp19107@medmail.com.cn

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摘要： 目的 探讨维持性血液透析抑郁患者血清部分细胞因子的改变及其临床意义。方法 选择在本院行维持性血液透析患者79例，根据汉密尔顿抑郁量表24项版本评分分为抑郁组和非抑郁组。采用酶联免疫吸附法（ELISA）测定两组病人血清IL-1β、IL-6和TNF-α。结果 根据汉密尔顿抑郁量表24项版本评分，维持性血液透析患者抑郁发生率57%；抑郁组与非抑郁组年龄、性别、透析时程、原发病构成、血红蛋白、血白蛋白、血肌酐水平等指标的差异无统计学意义；抑郁组血清IL-1β、IL-6水平增高，与非抑郁组比较差异有统计学意义（P0.05）；不同抑郁程度维持性血液透析患者血IL-6水平随着抑郁程度加重而增高，血IL-6与HAMD评分值正相关（r=0.380, P=0.01），血IL-1β、TNF-α水平与HAMD抑郁评分值无相关性（P＞0.05）。结论 维持性血液透析抑郁患者血IL-1β、IL-6表达水平增高，且IL-6与抑郁的严重程度具有相关性，有可能作为判断维持性血液透析病人抑郁严重程度的参考指标。

关键词: 维持性血液透析, 细胞因子, 抑郁, 汉密尔顿抑郁量表

Abstract: Objective To investigate the changes and clinical significance of serum cytokines in the maintenance hemodialysis (MHD) patients with depression. Method 79 cases of MHD patients were enrolled in this study, and by Hamilton Rating Scale for Depression (HAMD) scores, divided into two groups, depressive group and non-depressive group. Serum levels of cytokines including IL-1β, IL-6 and TNF-α were measured by enzyme-linked immunosorbent assay. Results The incidence of depression in MHD patients was 57%. The serum levels of IL-1β and IL-6 in depression group were much higher than those in non-depressive group (P<0.05), while TNF-α had no differences between these two groups. The serum levels of IL-6 were significant increased with the degrees of depression in MHD patients (P<0.05), and correlated positively with severity of depression in MHD patients. Conclusion The cytokines IL-1β，IL-6 may play important roles in the depression of MHD patients, especially IL-6, and the latter may used as predictive index for severity of depression in MHD patients.

Key words: Maintenance hemodialysis, Cytokine, Depression, Hamilton Rating Scale for Depression