中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (04): 207-209.doi: 10.3969/j.issn.1671-4091.2013.04.00

• 临床研究 • 上一篇    下一篇

维持性血液透析患者甲状腺功能减退症与贫血的临床相关性分析

徐丽娟1,卢晓昭1,邹晓荣2,李照辉3,罗会文2,于桂琴1   

  1. 1. 解放军第三二三医院
    2. 解放军第323医院
    3. 西安市建设西路解放军第323医院肾内科
  • 收稿日期:2012-11-05 修回日期:2013-01-28 出版日期:2013-04-12 发布日期:2013-07-01
  • 通讯作者: 徐丽娟 E-mail:13609296272@163.com
  • 基金资助:
    陕西省科技计划项目;兰州军区医药卫生计划项目

Clinical analysis of Hypothyroidism and anemia in patients with maintenance hemodialysis

  • Received:2012-11-05 Revised:2013-01-28 Online:2013-04-12 Published:2013-07-01

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摘要： 摘 要 目的：探讨维持性血液透析患者甲状腺功能减退症的发病情况，分析甲状腺功能减退症与肾性贫血的相关性，探讨积极治疗甲状腺功能减退症后肾性贫血的改善情况。方法：对过去7年间（2005年7月至2012年7月）我透析中心接受维持性血液透析治疗的患者甲状腺功能情况进行回顾性调查研究。使用Pearson’s χ2检验和Mann–Whitney U检验分析血液透析患者甲状腺功能减退症与临床特点的相关性，logistic回归分析用于贫血危险因素分析，配对t检验用于分析治疗甲减前后患者贫血状况的差异。结果：所有274例透析患者中，19例（6.9%）有甲状腺功能减退症，其中，男性发病率4.9%（7/142），女性发病率9.1%（12/132）。非甲减患者的血红蛋白水平高于甲减患者（u=15.262，ν=∞，P<0.001）。logistic回归分析表明Kt/V、血清铁蛋白、甲功与患者贫血具有相关性。配对t检验（t=5.115，ν=18，P<0.0001）提示治疗甲减前后，患者血红蛋白含量有明显差异。结论：维持性血液透析患者更容易并发甲状腺功能减退症，而甲状腺功能减退与患者血红蛋白含量有相关性，积极治疗甲减，可能有助于改善患者的贫血状况。

关键词: 维持性血液透析, 甲状腺功能减退症, 贫血

Abstract: ABSTRACT Objective: To analyze the incidence of hypothyroidism, and its relevance with anemia in maintenance hemodialysis (MHD). Methodology：The clinical records of MHD patients in our hemodialysis center in the past 7 years (Jul 1, 2005~ Jul 1, 2012) were retrospectively studied by chi-square test and Mann–Whitney U test. Correlation coefficients between hypothyroidism and anemia were assessed by logistic regression analysis. Paired t-test was done to assess hypothyroidism treatment effectiveness on anemia. Results: In our study, 19(6.9%) of 274 MHD patients had hypothyroidism, including 7 male (4.9%) and 9 female (9.1%). Patients without hypothyroidism had a higher level of hemoglobin(Hb) than those hypothyroidism patients (u=15.262,ν=∞, P<0.001). Furthermore, statistically significant correlations could be found between Hb and Kt/V, Ferritin and hypothyroidism. Hb level increased obviously after hypothyroidism treatment(t=5.115, ν=18, P<0.0001). Conclusion: Patients with maintenance hemodialysis had a high incidence of hypothyroidism, which might result in secondary anemia as effective hypothyroidism treatment could reduce the anemia.

Key words: maintenance hemodialysis, hypothyroidism, anemia