中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (05): 243-246.doi: 10.3969/j.issn.1671-4091.2013.05.00

• 临床研究 • 上一篇    下一篇

维持性血液透析患者25羟维生素D3对颈动脉内中膜厚度的影响的研究

赵华,常明,刘书馨,刘佳   

  1. 大连市中心医院肾内科
  • 收稿日期:2012-10-29 修回日期:2013-02-19 出版日期:2013-05-12 发布日期:2013-07-01
  • 通讯作者: 常明 mingchang@yeah.net E-mail:mingchang@yeah.com

Relationship between carotid intima-media thickness and 25-hydroxy vitamin D3 in maintenance hemodisysis uremic patients.

1, 1, 1   

  • Received:2012-10-29 Revised:2013-02-19 Online:2013-05-12 Published:2013-07-01

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摘要： 【摘要】目的 探讨维持性血液透析患者25羟维生素D3对颈动脉内中膜厚度（IMT）的影响及相关因素。方法 放射免疫分析法测定25羟维生素D3，超声检查测定颈动脉内中膜厚度；ELISA法测定血清淀粉样蛋白A、TNF-α浓度；检测血红蛋白、血浆白蛋白、尿素氮、肌酐、血脂、钙磷、甲状旁腺素等相关指标。结果 63例尿毒症维持性血液透析的患者中：1、IMT≥1.0mm的19例，IMT＜1.0mm的44例；2、两组之间25羟维生素D3与IMT呈负相关（P＜0.05）、血清淀粉样蛋白A、TNF-α、年龄、透析龄、收缩压、脉压、低密度脂蛋白等指标与IMT呈正相关（P＜0.05）；3、Pearson相关分析显示IMT与25羟维生素D3、血清淀粉样蛋白A、TNF-α显著相关（P＜0.05）。结论 IMT≥1.0mm占30.2%，25羟维生素D3水平与IMT呈负相关，提示维持性血液透析患者25羟维生素D3可能参与了心血管疾病的发生发展。

关键词: 【关键词】尿毒症, 血液透析, 25羟维生素D3, 颈动脉内中膜厚度

Abstract: [Abstract] Objective To investigate the relationship between carotid intima-media thickness and25-hydroxy vitamin D3 in maintenance hemodisysis uremic patients. Methods carotid intima-media thickness was examined by ultrasonograph. According to the carotid intima-media thickness value the maintenance hemodisysis uremic patients were divided into two sub-groups: IMT more than and equal 1.0mm, IMT less than 1.0mm. serum amyloid A and tumor necrosis factor-α were determined by ELISA. 25-hydroxy vitamin D3 were determined by Radioimmunoassay. Clinical data were collected. Results Among 63 the maintenance hemodisysis uremic patients, IMT more than and equal 1.0mm was revealed in 19 cases, IMT less than 1.0mm in 44 cases. 25-hydroxyvitamin D3 was negatively correlated with IMT. Serum amyloid A , tumor necrosis factor-α, age, hemodialysis time, systomic pressure, pulse pressure and low density lipoprotein cholesterol increased significantly in patients of IMT more than and equal 1.0mm,as compared with patients of IMT less than 1.0mm. Pearson correlation analysis showed IMT had the strongest correlation with 25-hydroxyvitamin D3 , serum amyloid A and tumor necrosis factor-α. Conclusion 30.2% patients, IMT was more than and equal 1.0mm. IMT had the strongest correlation with 25-hydroxyvitamin D3 , which may associate with advanced cardiovascular diseases in the maintenance hemodisysis patients.

Key words: [Key Words] uremic, hemodisysis, 25-hydroxyvitamin D3,, arotid intima-media thickness