中国血液净化

中国血液净化 ›› 2013, Vol. 12 ›› Issue (08): 419-424.doi: 10.3969/j.issn.1671-4091.2013.08.00

• 临床研究 • 上一篇    下一篇

有氧运动对维持性血液透析患者氧化应激及生存质量的影响

刘丽霞,贺晓蕾,郭宝春,邱晶,朱莲玉,张欣洲   

  1. 深圳市人民医院
  • 收稿日期:2013-02-26 修回日期:2013-05-11 出版日期:2013-08-12 发布日期:2013-08-12
  • 通讯作者: 张欣洲 xin.zhou@medmail.com.cn E-mail:15889692367@126.com

Effects of aerobic exercise on the oxidative stress and quality of life in maintenance hemodialysis patients

  • Received:2013-02-26 Revised:2013-05-11 Online:2013-08-12 Published:2013-08-12

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摘要： 【摘要】 目的 探讨12周透析中有氧运动对维持性血液透析(MHD)患者氧化应激及生存质量的影响，指导运动疗法在透析患者中的临床实践及科学运动处方的制定。 方法 选择深圳市人民医院血液透析中心34例MHD患者作为运动治疗组(完成研究27例)，选取同期我院血液透析中心一般情况相匹配的MHD患者27例作为对照组。运动组进行12周透析中有氧运动，对照组不采取任何干预。运动方式采用卧式踏车装置进行透析中有氧蹬车运动,每周3次，每次45分钟，持续12周。运动强度根据Borg’s 认知体力消耗量表确定。观察两组12周运动治疗前后一般生化资料、氧化应激指标、SF-36生存质量简表的差异。 结果 试验过程中运动组退出7例。所有受试对象试验过程中均未发生严重不良事件。运动组运动治疗12周后与治疗前相比，血清晚期氧化蛋白产物(AOPP)由21.97±3.04μmol/L降低到18.12±2.76μmol/L有显著差异(t=12.567, P 0.05）。通过12周有氧运动，运动组SF-36生存质量简表中生理功能(PF)、躯体疼痛(BP）、总体健康(GH）的得分较治疗前有显著提高（P均0.05）。此外，运动组躯体健康总测量(PCS) 的得分较治疗前有显著提高（t=2.921,P0.05）。 结论 12周透析中有氧运动能够显著降低MHD患者氧化应激终产物、提升抗氧化应激能力，并改善SF-36生存质量简表中PF、BP、GH、PCS的得分。此外，透析中卧式有氧蹬车运动设计科学，实施简便，安全显效，无明确不良事件，值得临床推广。

关键词: 血液透析, 氧化性应激, 有氧运动

Abstract: 【Abstract】Objective To investigate the effects of a 12-week intradialytic aerobic exercise on the oxidative stress and quality of life in maintenance hemodialysis (MHD) patients，in order to guide the clinical practice of exercise in dialysis patients.Methods 34 MHD patients from the hemodialysis center of Shenzhen People's Hospital were recruited for exercise group (27 patients completed this study). Other 27 patients were selected as the control group. A 12- week intradialytic aerobic exercise program in which subjects exercised 3 times a week (cycle ergometer, mini-stepper) for 45 minutes in each of the first 2 hours of hemodialysis, and the control group did not take any intervention. The prescription of exercise intensity was based on Borg’s Perceived Exertion Scale. General information, the oxidative stress indicators, and The Medical Outcomes Study Short Form 36-item (SF-36) questionnaire were performed at baseline and following the intervention. Results Seven cases quited in the exercise group. No serious adverse events happened in all subjects during the test. After 12-week intradialytic aerobic exercise, serum advanced oxidation protein products (AOPP) significantly decreased from 21.97 ± 3.04μmol / L to 18.12 ± 2.76μmol / L (t=12.567, P 0.05). Significant improvement in physical function (PF), bodily pain (BP), general health (GH)and physical component scale(PCS) was obtained in patients of treated group, while the role physical (RP), vitality (VT), social function (SF) , role emotional (RE) ,mental health (MH) and mental component scale remained unchanged. Conclusion A 12-week intradialytic aerobic exercise could reduce the oxidative stress products, enhance the ability of anti-oxidative stress and improve the quality of life in MHD patients. No severe advers effects were found.

Key words: Hemodialysis, Oxidative stress, aerobic exercise