中国血液净化 ›› 2015, Vol. 14 ›› Issue (01): 37-40.doi: :10.3969/j.issn.1671-4091.2015.01.010

• 临床研究 • 上一篇    下一篇

自体动静脉内瘘真性动脉瘤诊治

张丽红,詹申,王玉柱   

  1. 北京市海淀医院
  • 收稿日期:2014-07-07 修回日期:2014-09-05 出版日期:2015-01-12 发布日期:2015-01-12
  • 通讯作者: 王玉柱 wyz4417@126.com E-mail:zhanglihongzhu@sina.com

Diagnosis and management of true aneurysms of hemodialysis access fistulas

  • Received:2014-07-07 Revised:2014-09-05 Online:2015-01-12 Published:2015-01-12

摘要: 目的总结维持性血液透析患者自体动静脉内瘘真性动脉瘤的发病率、临床表现和处理方法。方法选择2009 年1 月~2013 年12 月因自体动静脉内瘘并发症就诊于北京市海淀医院(北京大学第三医院海淀院区)肾内科患者中存在静脉流出道瘤样扩张且瘤样扩张直径大于2cm,除外假性动脉瘤的患者,回顾性分析其人口学特征、临床表现、体格检查联合彩色多普勒超声、血管造影了解真性动脉瘤特征(位置,直径,是否继发血栓,是否存在狭窄,是否存在流出道梗阻)及处理方法。结果真性动脉瘤接受治疗者52 例,占同期因内瘘并发症住院患者的2.44%(52/2131),出现时间平均在内瘘建立后24±20 个月,动脉瘤平均直径3.12±1.24cm,合并瘤内血栓者18 例(34.61%);其中发生在穿刺部位者23 例(44.23%),全程瘤样扩张15 例(28.85%),吻合口部位14 例(26.92%);7 例(14.46%)患者因影响美观住院,45 例(86.54%)患者存在临床症状,其中皮肤变薄存在破裂风险最常见占25.0%(13/52),其次分别为静脉高压11.54%(6/52)、高输出量心力衰竭11.54%(6/52)、血流量不足11.54%(6/52)、缺血症状9.62%(5/52)、穿刺部位受限7.69%(4/52)、继发感染5.77%(3/52)、破裂出血3.85%(2/52)。合并穿刺区域静脉狭窄者10 例,非穿刺部位静脉流出道狭窄/闭塞2 例,中心静脉狭窄/闭塞4 例。5 例患者予结扎内瘘并切除动脉瘤,30 例患者行同侧肢体或对侧肢体内瘘重建或加切除动脉瘤,9 例患者存在瘘体部位狭窄、3 例患者存在中心静脉狭窄予血管成形,5 例患者存在内瘘血流量过高予环阻法限流。手术即刻成功率98.08%,未出现严重术后并发症。结论自体动静脉内瘘后,真性动脉瘤是相对少见的晚期并发症,临床表现多样,应根据发生部位结合患者自身血管条件采取个体化治疗。

关键词: 动静脉内瘘, 真性动脉瘤, 临床表现, 治疗

Abstract: Objective This study was designed to determine the clinical presentations, characteristics, and management of true aneurysms in dialysis access fistula. Methods Patients presenting arteriovenous ? fistula (AVF) functional problems or symptoms and aneurysmal enlargement of the outf low vein were reviewed.
Dilatation to more than three times of the native vessel diameter was considered to be aneurysm. Pseudoaneurysms were excluded from the study. Patients’demographics, aneurysm characteristics (location, diameter, thrombus, association with stenosis, and outf low obstruction), symptoms, type of treatment, and followup data were recorded. Results Fifty-two patients were found to have aneurysms of the outf low vein in upper extremities, accounting for 2.44% (52/2,131) of all hemodialysis access related complications. The average aneurysm size was 3.12±1.24cm, and the mean time from fistula establishment to presence of aneurysm was 24±20 months. Aneurysms located in cannulation areas in 23 patients (44.23%), along the venous outflow tract in 15 patients (28.85%), and in the juxta-anastomotic areas in 14 patients (26.92%). 7 patients (14.46%) were asymptomatic and the aneurysms were repaired for normal outlook. 45 patients (86.54%) were symptomatic, including skin changes (25%), venous hypertension (11.54%), high-output heart failure (11.54%), insufficient
blood flow (11.54%), steal syndrome (9.62%), limited area for cannulation (7.69%), infections (5.77%),and rupture with hemorrhage (3.85%). 9 patients (19.25%) presented vein stenosis in cannulation areas, 2 patients (3.85%) had venous outflow tract stenosis/occlusion not in the cannulation vein, and 4 patients (7.69%)
had central venous stenosis/occlusion. In the 5 patients with well- functional transplantation kidney, fistulawere ligated and the aneurysms were excised. In 30 patients, a new fistula at the same side or at opposite side was created with or without aneurysm excision. In 9 patients with stenosis at the aneurysm site, outflow tract venous angioplasty was conducted. In 3 patients with central venous stenosis/occlusion, angioplasty or stenting was used. In 5 patients with higher flow in fistula, banding aimed to restrict blood flow in the fistula was conducted. The immediate success rate was 98.08% without severe complications. Conclusion True aneurysm of autologous AVF is uncommon developing later after fistula creation with various clinical manifestations. This complication can be treated individually according to aneurysm site and vascular condition of the patient.

Key words: Arteriovenous fistula, true aneurysms, clinical manifestion, management