中国血液净化

中国血液净化 ›› 2017, Vol. 16 ›› Issue (09): 616-618.doi: 10.3969/j.issn.1671-4091.2017.09.008

• 综述 • 上一篇    下一篇

维持性血液透析患者高血压的管理现状

李梦婷1,李国宏1,张留平1,王越1,谢庆磊1   

  1. 1. 东南大学附属中大医院
  • 收稿日期:2017-03-24 修回日期:2017-06-06 出版日期:2017-09-12 发布日期:2017-09-12

The effect of acute kidney injury on other organs

  • Received:2017-03-24 Revised:2017-06-06 Online:2017-09-12 Published:2017-09-12

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摘要： 急性肾损伤(acute kidney injury, AKI)是危重患者常见并发症，也是患者预后不良的独立危险因素。目前尚无治疗AKI 的特异性药物。此外，虽然透析技术日益进步，透析依赖性的AKI 仍具有高死亡率。因此，仅仅关注AKI 患者肾脏损伤，对改善其预后是不够的。最新基础和临床研究阐述了AKI 患者肾脏和远处脏器之间复杂的相互作用。本综述旨在简述AKI 中肾脏与远处脏器间(心脏、肺脏、肝脏)交互作用的新进展及潜在治疗靶点，为临床治疗和预防AKI 后多脏器功能衰竭提供新思路。

关键词: 血液透析, 高血压, 管理

Abstract: Acute kidney injury (AKI) is the most common complication in critically ill patients, and is also an independent risk factor for unfavorable outcomes. There are no specific drugs for AKI at the present time. The mortality rate is higher in dialysis dependent AKI patients. It is insufficient to improve the outcome of AKI patients by merely focusing on kidney injury and renal dysfunction. Recent basic and clinical researches show that there is a complex cross-talk between kidney and other organs. This review aims to give a brief introduction about the recent progress and potential therapeutic targets in organ cross-talk between kidney and other organs (heart, lung and liver) in AKI, in order to provide new ideas for clinical treatment and prevention of multiple organ failure after AKI.

Key words: Acute kidney injury, Distant organ, Inflammation, Ischemia reperfusion injury