中国血液净化

中国血液净化 ›› 2017, Vol. 16 ›› Issue (09): 612-615.doi: 10.3969/j.issn.1671-4091.2017.09.008

• 综述 • 上一篇    下一篇

急性肾损伤对远处脏器损伤的影响

林其圣1,倪兆慧1   

  1. 1. 上海交通大学医学院附属仁济医院肾脏科
  • 收稿日期:2017-05-04 修回日期:2017-06-25 出版日期:2017-09-12 发布日期:2017-09-12
  • 通讯作者: 倪兆慧 profnizh@126.com E-mail:profnizh@126.com
  • 基金资助:

    国家自然科学基金面上项目（81570604）；国家自然科学基金面上项目（81370794）；上海市卫计委中西医结合重点项目（ZHYY-ZXYJHZX-1-02）

The effect of acute kidney injury on other organs

  • Received:2017-05-04 Revised:2017-06-25 Online:2017-09-12 Published:2017-09-12

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摘要： 急性肾损伤(acute kidney injury, AKI)是危重患者常见并发症，也是患者预后不良的独立危险因素。目前尚无治疗AKI 的特异性药物。此外，虽然透析技术日益进步，透析依赖性的AKI 仍具有高死亡率。因此，仅仅关注AKI 患者肾脏损伤，对改善其预后是不够的。最新基础和临床研究阐述了AKI 患者肾脏和远处脏器之间复杂的相互作用。本综述旨在简述AKI 中肾脏与远处脏器间(心脏、肺脏、肝脏)交互作用的新进展及潜在治疗靶点，为临床治疗和预防AKI 后多脏器功能衰竭提供新思路。

关键词: 急性肾损伤, 远处脏器, 炎症, 缺血再灌注损伤

Abstract: Acute kidney injury (AKI) is the most common complication in critically ill patients, and is also an independent risk factor for unfavorable outcomes. There are no specific drugs for AKI at the present time. The mortality rate is higher in dialysis dependent AKI patients. It is insufficient to improve the outcome of AKI patients by merely focusing on kidney injury and renal dysfunction. Recent basic and clinical researches show that there is a complex cross-talk between kidney and other organs. This review aims to give a brief introduction about the recent progress and potential therapeutic targets in organ cross-talk between kidney and other organs (heart, lung and liver) in AKI, in order to provide new ideas for clinical treatment and prevention of multiple organ failure after AKI.

Key words: acute kidney injury, distant organ, inflammation, ischemia reperfusion injury