中国血液净化

›› 2003, Vol. 2 ›› Issue (4): 183-185.

• 论著 • 上一篇    下一篇

腹膜透析患者低白蛋白血症对其左心室结构和功能的影响

朱 萍 吴 佩 钱 莹 汪关煜   

  1. 200025 上海，上海第二医科大学瑞金医院肾内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-04-19 发布日期:2003-04-19

  • Received:1900-01-01 Revised:1900-01-01 Online:2003-04-19 Published:2003-04-19

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摘要： 目的 探讨腹膜透析（ PD）患者诸因素对左心室结构和功能的影响。方法 20例PD患者，所有 患者进行超声心动图与心功能检测，并根据Devereux公式计算左心室心肌重量指数（LVMI）。将患者的年龄、PD时间、Kt/v、Hb、TG、Tch、血浆白蛋白（SA）、nPCR、CRP、PTH、PD超滤量与左心室射血分数（EF）、LVMI和左心室舒张早期和晚期最大血流速度比（E/A）进行逐步回归分析。患者的收缩压与LVMI，CRP、nPCR分别与SA作直线相关分析。 结果 LVH发生率为55%，E/A<1占95%，逐步回归分析显示：SA与LVMI呈显著负相关（γ2=0.3619， P=0.005），年龄与 E/A呈负相关（γ2=0.58， P=0.0245）。直线相关分析示收缩压与 LVMI呈正相关。CRP与SA呈显著负相关，nPCR与SA呈正相关。SA<30g/L者，LVH发生率为73%，较高于SA≥30g/L者，左心室舒张功能障碍前者较后者为多。 结论 PD患者LVH发生率高，低白蛋白血症是值得关注的重要危险因素之一。

关键词: 腹膜透析, 低白蛋白血症, 超声心动图, 左心室肥厚

Abstract: Objective To study the influcence of hypoalbuminaemia on left ventricular construction and cardiac function in PD patients. Methods In this study ,echocardiography and cardiac function were performed in 20 PD patients. According to Devereux's formula, LV mass index (LVMI) was caculated. We did the stepwise regression analysis between patient's age,time of PD、Kt/V、Hb、TG、Tch、SA、nPCR、CRP、PTH、filtration volume of PD and EF、LVMI、E/A. We also did the linear regression analysis between systolic blood pressure and LVMI of these patients. The linear regression analysis between CRP, nPCR and SA were also performed. Results The incidence of LVH was 55%. EA<1 was 95%.Stepwise regression analysis showed that SA was significantly correlated with LVMI(γ2=0.3619, P=0.005). The age of patients was inversely correlated with E/A (γ2=0.58, P=0.0245). Linear regression analysis showed that systolic blood pressure was positively correlated with LVMI. CRP was negatively correlated with SA and n PCR was positively correlated with SA. The incidence of LVH was 73% in the patients whose serum albumin was less than 30 g/L.It was higher than that of patients whose serum albumin was more than 30g/L. The impairment of diastolic function of left ventricular in former group was more than that of latter group. Conclusion The incidence of LVH was high. Hypoalbuminaemia was one of the risk factors in PD patients.

Key words: Hypoalbuminaemia, Echocardiography, Left ventricular hypertrophy