中国血液净化

中国血液净化 ›› 2025, Vol. 24 ›› Issue (01): 49-53.doi: 10.3969/j.issn.1671-4091.2025.01.010

• 综述 • 上一篇    下一篇

连续性肾脏替代治疗枸橼酸盐置换液研究进展

童 双   林乔轩   王敏敏   王 磊   

  1. 200124 上海，1百特(中国)投资有限公司医学事务与临床发展部
    100044 北京，2北京大学人民医院肾内科
  • 收稿日期:2024-05-23 修回日期:2024-07-19 出版日期:2025-01-12 发布日期:2025-01-12
  • 通讯作者: 王磊 E-mail:bjwangl@163.com

Research progress in the citrate-based replacement fluids for continuous renal replacement therapy

TONG Shuang, LIN Qiao-xuan, WANG Min-min, WANG Lei   

  1. Department of Medical Affairs and Clinical Development, Baxter China Ltd, Shanghai 200031, China; 2Department of Nephrology, Peking University People's Hospital, Beijing 100044, China
  • Received:2024-05-23 Revised:2024-07-19 Online:2025-01-12 Published:2025-01-12
  • Contact: 100044 北京，2北京大学人民医院肾内科 E-mail:bjwangl@163.com

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摘要： 成功的抗凝是保障连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)顺利实施的关键，国内外相关指南一致推荐局部枸橼酸抗凝作为首选。既往临床使用的传统局部枸橼酸抗凝剂操作复杂，并有电解质紊乱及酸碱失衡的潜在风险，导致局部枸橼酸抗凝临床普及受阻。新型枸橼酸盐置换液作为血液滤过置换液的同时，兼具抗凝功效，它的出现弥补了既往局部枸橼酸抗凝剂的不足。本文从抗凝效果、治疗效率、安全性等角度对枸橼酸盐置换液相关临床研究进行综述，以期对其发展及现状进行全面的介绍，并为临床应用提供理论支持。

关键词: 连续性肾脏替代治疗, 局部枸橼酸抗凝, 枸橼酸盐置换液

Abstract: Anticoagulation strategy ensures filter patency and delivery of an adequate continuous renal replacement therapy (CRRT) dose. Most guidelines recommend the regional citrate anticoagulation (RCA) as the first-line method for patients requiring CRRT. Previous use of the traditional regional citrate anticoagulation had several drawbacks such as complex operation, risks of acid-base imbalance and metabolic disorders, leading to the restriction of its clinical applications. By contrast, citrate-based replacement fluids solve these deficiencies. This article reviews the research progress in citrate-based replacement fluids from point of view of  anticoagulation effectiveness, treatment efficiency and security.

Key words: Continuous renal replacement therapy, Regional citrate anticoagulation, Citrate-based , replacement fluid

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